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Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

21 October 2020

Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Edoardo Saccenti and Mattias Svensson

Latest posts

  • Neutrophil-derived reactive agents induce a speB negative phenotype in Streptococcus pyogenes

    5 September 2023
  • Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

    5 September 2023
  • Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study

    5 September 2023
  • Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

    4 May 2022
  • Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections

    15 July 2021

Archive

  • 2023
    • Neutrophil-derived reactive agents induce a speB negative phenotype in Streptococcus pyogenes

    • Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

    • Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study

  • 2022
    • Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

  • 2021
    • Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections

    • New biomarkers for life-threatening soft tissue infections

    • 31st May -1st June 2021, PerAID Annual Meeting

    • 18-19th May 2021, ERAPerMed Midterm Review Seminar

    • Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

  • 2020
    • Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

    • Necrotizing Soft Tissue Infections Clinical and Pathogenic Aspects

    • Host and Pathogen Communication in the Respiratory Tract: Mechanisms and Models of a Complex Signaling Microenvironment

    • 28th January 2021, PerMIT and PerAID Project Meetings

    • 4th September 2020, PerMIT Annual Meeting

    • 21st August, 2020, Doctoral Thesis Defense, Puran Chen

    • Research highlighted in “Forskning och Framsteg”

    • Risk factors and predictors of mortality in Streptococcal necrotizing soft-tissue infections: A multicenter prospective study

    • Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections.

  • 2019
    • Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections

    • 27-29 May 2020, PerAID Annual Meeting

    • MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

    • Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

    • 23 – 26 Oct 2019, PerMIT 1st annual meeting

    • 17 – 18 Sept 2019: Nordic PerMed workshop, Oslo

    • Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

    • Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response.

    • Necrotizing Soft Tissue Infections S.aureus – but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

    • Health-Related Quality of Life Is Decreased After Necrotizing Soft-Tissue Infections

    • 12 – 15 sept 2019: Nordic Society for Clinical Microbiology and Infectious Diseases (NSCMID), Trondheim.

    • Necrotizing skin and soft-tissue infections in the intensive care unit.

    • Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

    • Almedalsveckan

    • GenomeWeb highlighting PerAID in their publication of Nordforsk projects

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