PerMIT

Personalized Medicine in Infections: from Systems Biomedicine and Immunometabolism to Precision Diagnosis and Stratification Permitting Individualized Therapies (PerMIT)

PerMIT is supported by the ERAPerMed initative for joint transnational projects on Personalized Medicine  – smart combination of pre-clinical and clinical research with data and ICT solutions. To achieve its objective, the project builds on a transnational interdisciplinary team of clinicians, experimentalists, bioinformaticians and computational modellers. Partners are supported by their respective national funding agency including the Swedish Research Council, Innovationsfonden (Denmark), the Research Council of Norway, ZonMw (The Netherlands Organisation for Health Research and Development) (The Netherlands) and X (Germany).

The PerMIT-project focuses on life-threatening infectious diseases, including the destructive necrotizing soft tissue infections (NSTI) and the large group of sepsis patients. The severity of these infections is dictated by the individual’s response to the pathogen and greatly depends on subject-specific host-pathogen interactions. For this reason, personalized therapeutic strategies targeting both the pathogen and host response are needed. To achieve this, PERMIT builds on the knowledge and resources created in the EU FP7-project INFECT including the world’s largest multicenter, prospectively enrolled patient cohort on NSTI, a biobank, multi-omics data, strategic data stewardship and pathophysiologic models. Based on INFECT data, one focus area is immunometabolism and its contribution to disease. PERMIT will move towards preclinical validation of disease signatures, underlying mechanisms and biomarkers with the aim of translating these findings into improved or novel diagnostics, and to demonstrate the clinical feasibility and potential benefit of a personalized medicine approach to the treatment. The project will focus on delineating mechanisms at the individual level in NSTI patients and will extend the findings into the larger field of sepsis.   

Partners and national funding agencies

Funding scheme: ERAPerMed initative for joint transnational projects on Personalized Medicine – smart combination of pre-clinical and clinical research with data and ICT solutions.

Karolinska Institutet, Stockholm Sweden

Karolinska Institutet, Stockholm Sweden

Center for Infectious Medicine ANA Futura Laboratory

Key contributors:

Anna Norrby-Teglund

Anna Norrby-Teglund

Professor
Email: anna.norrby-teglund@ki.se
Phone: +46 – 8 – 524 823 54
Website: https://ki.se/en/medh/anna-norrby-teglund-group

Mattias Svensson

Mattias Svensson

Ph.D., Associate Professor
Email: mattias.svensson@ki.se
Phone: +46 – 8 – 524 83773
Website: https://ki.se/en/medh/mattias-svensson-group

Kristoffer Strålin

Kristoffer Strålin

M.D., PhD., Associate Professor, Senior Consultant
Department of Infectious Diseases, I73 Karolinska University Hospital, Huddinge
Email: kristoffer.stralin@ki.se
Phone: +46705927532, +46858580142

Copenhagen University/Rigshospitalet, Copenhagen; Denmark

Copenhagen University/Rigshospitalet, Copenhagen; Denmark

Key contributors:

Ole Hyldegaard

Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
Email: Ole.Hyldegaard@regionh.dk

University of Bergen/Haukeland University Hospital, Bergen, Norway

University of Bergen/Haukeland University Hospital, Bergen, Norway

Key contributors:

Steinar Skrede

M.D, Dr.med, Dept. Director, Professor
Dept. of Medicine, Haukeland University Hospital, Bergen, Norway
Dept. of Clinical Science, University of Bergen, Bergen,Norway
Email: Steinar.skrede@helse-bergen.no
Phone: +47-992 52 796

Trond Bruun

M.D., Ph.D., Senior consultant, Dept. of Medicine, Haukeland University Hospital, Bergen, Norway
Email: trond.bruun@helse-bergen.no
Phone: +47-478 97 356

Oddvar Oppegaard

M.D., Ph.D., Senior consultant, Dept. of Medicine, Haukeland University Hospital, Bergen, Norway
Email: Oddvar.Oppegaard@helse-bergen.no
Phone: +47-975 85 709

Knut Anders Mosevoll

M.D., Ph.D., Senior consultant, Dept. of Medicine, University Hospital, Bergen, Norway
E-mail: Knut.Anders.Mosevoll@helse-bergen.no
Phone: +47-95742184

LifeGlimmer GmbH, Berlin, Germany

LifeGlimmer GmbH, Berlin, Germany

Wageningen University & Research, Wageningen, the Netherlands

Wageningen University & Research, Wageningen, the Netherlands

Laboratory of Systems and Synthetic Biology

Key contributors:

Edoardo Saccenti

Assistant Professor
Email: edoardo.saccenti@wur.nl
Phone: +31 (0)317 486948
Website: https://www.systemsbiology.nl/edoardo-saccenti/

Rode Kruis Ziekenhuis (Red Cross Hospital), Beverwijk, The Netherlands

Rode Kruis Ziekenhuis (Red Cross Hospital), Beverwijk, The Netherlands

Key contributors:

Annebeth de Vries

M.D., Ph.D., Senior consultant Department of Surgery and Burn Unit.
Email: adevries@rkz.nl
Phone: +31 (0) 251 26 4917
Website: https://www.rkz.nl/dutchburncentrebeverwijk

Anouk Pijpe

Ph.D., Clinical epidemiologist.
Email: apijpe@rkz.nl
Phone: +31 (0) 251 26 5794
Website: https://www.rkz.nl/dutchburncentrebeverwijk