PUBLICATIONS

Here we will continuously publish articles from studies within the projects PerAid, PerMIT and INFECT.

Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections

Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections

Muhammad Afzal, Edoardo Saccenti, Martin Madsen, Marco Bo Hansen, Ole Hyldegaard, Steinar Skrede, vitor martins dos santos, Anna Norrby Teglund and Mattias Svensson

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

Johanna EmgårdHelena Bergsten, John K. McCormickIsrael BarrantesSteinar Skrede, Johan K. Sandberg and Anna Norrby-Teglund

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

Siemens N., Oehmcke-Hecht S., Hoßmann J.. Skorka S.B., Nijhuis R.H.T. Ruppen C., Skrede S., · Rohde M., Schultz D., Lalk M.,  Itzek A., Pieper D.H., van den Bout C.J.,  Claas E.C.J., Kuijper E.J., Mauritz R., Sendi P., Wunderink H.F., and Norrby-Teglund A.

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

Robert Thänert, Andreas Itzek, Jörn Hoßmann, Domenica Hamisch, Martin Bruun Madsen, Ole Hyldegaard, Steinar Skrede, Trond Bruun & Anna Norrby-Teglund INFECT study group, Eva Medina & Dietmar H. Pieper, Nature Communications, 26 August 2019, volume 10, Article number: 3846.

Patient’s characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study

Patient’s characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study

Martin Bruun Madsen, Steinar Skrede, Anders Perner, Per Arnell, Michael Nekludov, Trond Bruun, Ylva Karlsson, Marco Bo Hansen, Peter Polzik, Morten Hedetoft, Anders Rosén, Edoardo Saccenti, François Bergey, Vitor A. P. Martins dos Santos, INFECT study group, Anna Norrby-Teglund, Ole Hyldegaard, Intensive Care Medicine, September 2019, Volume 45, Issue 9, pp 1241–1251, Doi:10.1007/s00134-019-05730-x, PMID: 31440795

Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

Norrby-Teglund A, Siemens N. Clin Infect Dis. 2019 Jul 23. pii: ciz427. doi: 10.1093/cid/ciz427. [Epub ahead of print]. PMID: 31334751

Necrotizing skin and soft-tissue infections in the intensive care unit.

Necrotizing skin and soft-tissue infections in the intensive care unit.

Peetermans M, de Prost N, Eckmann C, Norrby-Teglund A, Skrede S, De Waele JJ. Clin Microbiol Infect. 2019 Jul 5. pii: S1198-743X(19)30382-9. doi: 10.1016/j.cmi.2019.06.031. [Epub ahead of print] Review. PMID:  31284035

Necrotizing Soft Tissue Infections S.aureus - but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

Necrotizing Soft Tissue Infections S.aureus – but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

Baude J, Bastien S, Gillet Y, Leblanc P, Itzek A, Tristan A, Bes M, Duguez S, Moreau K, Diep BA, Norrby-Teglund A, Henry T, Vandenesch F; INFECT Study Group. J Infect Dis. 2019 Apr 19. pii: jiz167. doi: 10.1093/infdis/jiz167. [Epub ahead of print] PMID:31001627

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response.

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response.

Keller N, Woytschak J, Heeb LEM, Marques Maggio E, Mairpady Shambat S, Snäll J, Hyldegaard O, Boyman O, Norrby-Teglund A, Zinkernagel AS. J Invest Dermatol. 2019 Jun;139(6):1284-1293. doi: 10.1016/j.jid.2018.11.027. Epub 2018 Dec 10. PMID: 30543898

Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

Tarnutzer A, Andreoni F, Keller N, Zürcher C, Norrby-Teglund A, Schüpbach RA, Zinkernagel AS. Clin Microbiol Infect. 2019 Apr;25(4):512.e7-512.e13. doi: 10.1016/j.cmi.2018.07.007. Epub 2018 Jul 17. PMID: 30025835