PUBLICATIONS

Here we will continuously publish articles from studies within the projects PerAid, PerMIT and INFECT.

Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

Sanjeevan Jahagirdar, Lorna Morris, Nirupama Benis, Oddvar Oppegaard, Mattias Svenson, Ole Hyldegaard, Steinar Skrede, Anna Norrby-Teglund, INFECT Study group, Vitor A. P. Martins dos Santos, Edoardo Saccenti

BMC Medicine, 2022; volume 20: 173

Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models

Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models

H Bergsten, L M Palma Medina, M Morgan, K Moll, D H Skutlaberg, S Skrede, T Wajima, M Svensson, A Norrby-Teglund

Antimicrob Agents Chemother, 2021; 65:e0065821

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

Magda Lourda, Majda Dzidic, Laura Hertwig, Helena Bergsten, Laura M Palma Medina, Indranil Sinha, Egle Kvedaraite, Puran Chen, Jagadeeswara R Muvva , Jean-Baptiste Gorin, Martin Cornillet, Johanna Emgård, Kirsten Moll, Marina García, Kimia T Maleki, Jonas Klingström, Jakob Michaëlsson, Malin Flodström-Tullberg, Susanna Brighenti, Marcus Buggert, Jenny Mjösberg, Karl-Johan Malmberg, Johan K Sandberg, Jan-Inge Henter, Elin Folkesson, Sara Gredmark-Russ, Anders Sönnerborg, Lars I Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Strålin, Hans-Gustaf Ljunggren, Niklas K Björkström, Mattias Svensson, Andrea Ponzetta, Anna Norrby-Teglund, Benedict J Chambers, Karolinska KI/K COVID-19 Study Group

Proc Natl Acad Sci U S A, 2021; 118:e2109123118

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingström, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars I. Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Strålin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Björkström, Jan-Inge Henter, Mattias Svensson, and Karolinska KI/K COVID-19 Study Group

PNAS February 9, 2021;118:e2018587118

Evaluation of Single Sample Network Inference Methods for Metabolomics-Based Systems Medicine

Evaluation of Single Sample Network Inference Methods for Metabolomics-Based Systems Medicine

Sanjeevan Jahagirdar and Edoardo Saccenti

Journal of Proteome Research, 2021, 20, 1, 932–949

Soluble ICAM-1 is modulated by hyperbaric oxygen treatment and correlates with disease severity and mortality in patients with necrotizing soft-tissue infection

Soluble ICAM-1 is modulated by hyperbaric oxygen treatment and correlates with disease severity and mortality in patients with necrotizing soft-tissue infection

Morten Hedetoft, Claus Moser, Peter Østrup Jensen, Julie Vinkel and Ole Hyldegaard
Journal of Applied Physiology, 2021;130:729-736

Phenotype and multi-omics comparison of Staphylococcus and Streptococcus uncovers pathogenic traits and predicts zoonotic potential

Phenotype and multi-omics comparison of Staphylococcus and Streptococcus uncovers pathogenic traits and predicts zoonotic potential

Niels A. Zondervan, Vitor A. P. Martins dos Santos, Maria Suarez-Diez and Edoardo Saccenti

BMC Genomics, 2021;22: Article 102

Host and Pathogen Communication in the Respiratory Tract: Mechanisms and Models of a Complex Signaling Microenvironment

Host and Pathogen Communication in the Respiratory Tract: Mechanisms and Models of a Complex Signaling Microenvironment

Samuel B Berry, Amanda J Haack, Ashleigh B Theberge, Susanna Brighenti, Mattias Svensson

Frontiers in Medicine, 2020, Volume 7, Article 537

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

Helena BergstenMartin Bruun MadsenFrancois BergeyOle HyldegaardSteinar SkredePer ArnellOddvar OppegaardAndreas ItzekAnders PernerMattias SvenssonAnna Norrby-TeglundINFECT Study Group

Clinical Infectious Diseases, Volume 71, Issue 7, 1 October 2020, Pages 1772–1775

Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study

Non-purulent skin and soft tissue infections: predictive power of a severity score and the appropriateness of treatment in a prospective cohort

Non-purulent skin and soft tissue infections: predictive power of a severity score and the appropriateness of treatment in a prospective cohort

Eivind RathSteinar SkredeOddvar Oppegaard and Trond Bruun

Infectious Diseases, 2020, 52:361-371

Corruption of the Pearson correlation coefficient by measurement error and its estimation, bias, and correction under different error models

Corruption of the Pearson correlation coefficient by measurement error and its estimation, bias, and correction under different error models

Edoardo Saccenti, Margriet H. W. B. Hendriks and Age K. Smilde

Scientific Reports, 2020;10: Article 438

Incidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005-2018: a Danish nationwide register-based cohort study

Incidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005-2018: a Danish nationwide register-based cohort study

Morten HedetoftMartin Bruun MadsenLærke Bruun Madsen and Ole Hyldegaard

BMJ Open, 2020;10:e041302

The INFECT-Project: An International and Multidisciplinary Project on Necrotizing Soft Tissue Infections

The INFECT-Project: An International and Multidisciplinary Project on Necrotizing Soft Tissue Infections

Mattias Svensson, Anna Norrby-Teglund

Advances in Experimental Medicine and Biology, 2020;1294:1-6

Necrotizing Soft Tissue Infections: Case Reports from the Patients Prospective

Necrotizing Soft Tissue Infections: Case Reports from the Patients Prospective

Doreen Cartledge, Lucy Dove, Emma Richardson, Robert Wilkie

Advances in Experimental Medicine and Biology, 2020;1294:7-20

Necrotizing Soft Tissue Infections: Case Reports, from the Clinician’s Perspectives

Necrotizing Soft Tissue Infections: Case Reports, from the Clinician’s Perspectives

Torbjørn Nedrebø and Steinar Skrede

Advances in Experimental Medicine and Biology, 2020;1294:21-37

Necrotizing Soft-Tissue Infections: Clinical Features and Diagnostic Aspects

Necrotizing Soft-Tissue Infections: Clinical Features and Diagnostic Aspects

Martin Bruun Madsen, Per Arnell and Ole Hyldegaard

Advances in Experimental Medicine and Biology, 2020;1294:39-52

Microbiological Etiology of Necrotizing Soft Tissue Infections

Microbiological Etiology of Necrotizing Soft Tissue Infections

Steinar Skrede, Trond Bruun, Eivind Rath, Oddvar Oppegaard

Advances in Experimental Medicine and Biology, 2020;1294:53-71

Beta-Hemolytic Streptococci and Necrotizing Soft Tissue Infections

Beta-Hemolytic Streptococci and Necrotizing Soft Tissue Infections

Trond Bruun, Eivind Rath, Oddvar Oppegaard, Steinar Skrede

Advances in Experimental Medicine and Biology, 2020;1294:73-86

Treatment of Necrotizing Soft Tissue Infections: Antibiotics

Treatment of Necrotizing Soft Tissue Infections: Antibiotics

Oddvar Oppegaard and Eivind Rath

Advances in Experimental Medicine and Biology, 2020;1294:87-103

Treatment of Necrotizing Soft Tissue Infections: IVIG

Treatment of Necrotizing Soft Tissue Infections: IVIG

Martin Bruun Madsen, Helena Bergsten and Anna Norrby-Teglund

Advances in Experimental Medicine and Biology, 2020;1294:105-125

Pathogenic Mechanisms of Streptococcal Necrotizing Soft Tissue Infections

Pathogenic Mechanisms of Streptococcal Necrotizing Soft Tissue Infections

Nikolai Siemens Johanna SnällMattias Svensson and Anna Norrby-Teglund

Advances in Experimental Medicine and Biology,  2020;1294:127-150

Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections

Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections

Suba Nookala, Karthickeyan Chella KrishnanSanthosh MukundanMalak Kotb

Advances in Experimental Medicine and Biology, 2020;1294:151-166.

Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Edoardo Saccenti and Mattias Svensson

Advances in Experimental Medicine and Biology,  2020;1294:167-186

Systems and Precision Medicine in Necrotizing Soft Tissue Infections

Systems and Precision Medicine in Necrotizing Soft Tissue Infections

Vitor A P Martins Dos SantosChristopher Hardt, Steinar SkredeEdoardo Saccenti

Advances in Experimental Medicine and Biology, 2020;1294:187-207

Models of the lung tissue microenvironment for studies of human myeloid cell function

Necrotizing skin and soft-tissue infections in the intensive care unit

Necrotizing skin and soft-tissue infections in the intensive care unit

M.Peetermans, N.de Prost, C.Eckmann, A.Norrby-Teglund, S.Skrede, J.J.De Waele

Clinical Microbiology and Infection;  2020, 26:8-17

 

Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections

Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections

Muhammad Afzal, Edoardo Saccenti, Martin Madsen, Marco Bo Hansen, Ole Hyldegaard, Steinar Skrede, vitor martins dos santos, Anna Norrby Teglund and Mattias Svensson

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

Johanna EmgårdHelena Bergsten, John K. McCormickIsrael BarrantesSteinar Skrede, Johan K. Sandberg and Anna Norrby-Teglund

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

Siemens N., Oehmcke-Hecht S., Hoßmann J.. Skorka S.B., Nijhuis R.H.T. Ruppen C., Skrede S., · Rohde M., Schultz D., Lalk M.,  Itzek A., Pieper D.H., van den Bout C.J.,  Claas E.C.J., Kuijper E.J., Mauritz R., Sendi P., Wunderink H.F., and Norrby-Teglund A.

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

Robert Thänert, Andreas Itzek, Jörn Hoßmann, Domenica Hamisch, Martin Bruun Madsen, Ole Hyldegaard, Steinar Skrede, Trond Bruun & Anna Norrby-Teglund INFECT study group, Eva Medina & Dietmar H. Pieper, Nature Communications, 26 August 2019, volume 10, Article number: 3846.

Patient’s characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study

Patient’s characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study

Martin Bruun Madsen, Steinar Skrede, Anders Perner, Per Arnell, Michael Nekludov, Trond Bruun, Ylva Karlsson, Marco Bo Hansen, Peter Polzik, Morten Hedetoft, Anders Rosén, Edoardo Saccenti, François Bergey, Vitor A. P. Martins dos Santos, INFECT study group, Anna Norrby-Teglund, Ole Hyldegaard, Intensive Care Medicine, September 2019, Volume 45, Issue 9, pp 1241–1251, Doi:10.1007/s00134-019-05730-x, PMID: 31440795

Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

Norrby-Teglund A, Siemens N. Clin Infect Dis. 2019 Jul 23. pii: ciz427. doi: 10.1093/cid/ciz427. [Epub ahead of print]. PMID: 31334751

Necrotizing skin and soft-tissue infections in the intensive care unit.

Necrotizing skin and soft-tissue infections in the intensive care unit.

Peetermans M, de Prost N, Eckmann C, Norrby-Teglund A, Skrede S, De Waele JJ. Clin Microbiol Infect. 2019 Jul 5. pii: S1198-743X(19)30382-9. doi: 10.1016/j.cmi.2019.06.031. [Epub ahead of print] Review. PMID:  31284035

Necrotizing Soft Tissue Infections S.aureus - but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

Necrotizing Soft Tissue Infections S.aureus – but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

Baude J, Bastien S, Gillet Y, Leblanc P, Itzek A, Tristan A, Bes M, Duguez S, Moreau K, Diep BA, Norrby-Teglund A, Henry T, Vandenesch F; INFECT Study Group. J Infect Dis. 2019 Apr 19. pii: jiz167. doi: 10.1093/infdis/jiz167. [Epub ahead of print] PMID:31001627

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response.

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response.

Keller N, Woytschak J, Heeb LEM, Marques Maggio E, Mairpady Shambat S, Snäll J, Hyldegaard O, Boyman O, Norrby-Teglund A, Zinkernagel AS. J Invest Dermatol. 2019 Jun;139(6):1284-1293. doi: 10.1016/j.jid.2018.11.027. Epub 2018 Dec 10. PMID: 30543898

Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

Tarnutzer A, Andreoni F, Keller N, Zürcher C, Norrby-Teglund A, Schüpbach RA, Zinkernagel AS. Clin Microbiol Infect. 2019 Apr;25(4):512.e7-512.e13. doi: 10.1016/j.cmi.2018.07.007. Epub 2018 Jul 17. PMID: 30025835