PerAID

PerAID is supported by the Nordforsk initiative in Innovations in Personalized Medicine towards implementation of personalized medicine in health care. Partners are supported by their respective national funding agency, including Vinnova (Sweden), Innovationsfonden (Denmark), and the Research Council of Norway. 

Personalized Medicine in Acute Infectious Diseases (PerAID)

The PerAID project proposes to boost personalized medicine (PM) in severe infectious diseases, specifically focusing on the life-threatening necrotizing soft tissue infections (NSTI) as well as the large heterogeneous group of sepsis patients. Personalized medicine is a neglected, albeit much desired, development in the field of acute infectious diseases. The patient population is highly heterogeneous with different pathogens, pathogenic mechanisms, as well as varying predisposing host factors, and importantly, a dysregulated host response to infection is directly linked to severity and outcome of severe infections such as sepsis and NSTI. Hence, tailored immunotherapy in stratified patients holds great potential.

PerAID builds on the results, advances and resources created in the EU FP7-project INFECT, including the world’s largest patient cohort on NSTI (Scandinavian patients enrolled by PerAIDs partners from Denmark, Norway and Sweden), biobank, multi-omics data, and pathophysiologic models. Using these resources and an extended Nordic consortium including also the Norwegian sepsis center (www.sepsis.no) enables PerAID to advance to the next phase of implementing PM in these life-threatening infections. A key activity of PerAID is to create a Nordic platform for PM in infectious diseases to enable the establishment of harmonized, comprehensive and accessible databases for clinical and omics data, as well as biobanks for patients with NSTI and sepsis, and an interdisciplinary knowledge centre embedded in a Responsible Research & Innovation (RRI) framework. This platform will provide a forum for interdisciplinary research activities and will promote quality controlled, standardized, and accessible patient cohorts, registries, biobanks and omics data. This will greatly enable high quality PM activities in the field of infectious diseases, which will benefit not only researchers and clinicians, but also other stakeholders, i.e. industry, patients and civil society, as well as key actors on the international arena including European organisations and WHO. In PerAID we seek to identify disease signatures and biomarkers of diagnostic or prognostic value, as well as identify tailored therapeutic strategies in specific patient groups.

Partners and national funding agencies

 

Funding scheme: Nordforsk initiative in Innovations in Personalized Medicine towards implementation of personalized medicine in health care.

Karolinska Institutet, Stockholm Sweden

Karolinska Institutet, Stockholm Sweden

Center for Infectious Medicine ANA Futura Laboratory

With funding from Vinnova

With funding from Vinnova

Key contributors:

Anna Norrby-Teglund

Professor
Email: anna.norrby-teglund@ki.se
Phone: +46 – 8 – 524 823 54
Website: https://ki.se/en/medh/anna-norrby-teglund-group

Mattias Svensson

Ph.D., Associate Professor
Email: mattias.svensson@ki.se
Phone: +46 – 8 – 524 83773
Website: https://ki.se/en/medh/mattias-svensson-group

Kristoffer Strålin

M.D., PhD., Associate Professor, Senior Consultant
Department of Infectious Diseases, I73
Karolinska University Hospital, Huddinge
Email: kristoffer.stralin@ki.se
Phone: +46705927532, +46858580142

University of Bergen/Haukeland University Hospital, Bergen, Norway

University of Bergen/Haukeland University Hospital, Bergen, Norway

Key contributors:

Steinar Skrede

M.D, Dr.med, Dept. Director, Professor
Dept. of Medicine, Haukeland University Hospital, Bergen, Norway
Dept. of Clinical Science, University of Bergen, Bergen,Norway
Email: Steinar.skrede@helse-bergen.no
Phone:+47-992 52 796

Trond Bruun

M.D., Ph.D., Senior consultant, Dept. of Medicine, Haukeland University Hospital, Bergen, Norway
Email: trond.bruun@helse-bergen.no
Phone:+47-478 97 356

Oddvar Oppegaard

M.D., Ph.D., Senior consultant, Dept. of Medicine, Haukeland University Hospital, Bergen, Norway
Email: Oddvar.Oppegaard@helse-bergen.no
Phone:+47-975 85 709

Knut Anders Mosevoll

M.D., Ph.D., Senior consultant, Dept. of Medicine, University Hospital, Bergen, Norway
E-mail: Knut.Anders.Mosevoll@helse-bergen.no
Phone: +47-95742184

Norwegian University of Science and Technology, Trondheim, Norway

Norwegian University of Science and Technology, Trondheim, Norway

Gemini Center for Sepsis Research

Key contributors:

Erik Solligård

MD PhD, Professor and Senior Consultant in Intensive Care Medicine Director Gemini Center Sepsis Research, NTNU
St Olavs Hospital, University Hospital Trondheim
Email: erik.solligard@ntnu.no
Phone: +47 41452673
Website: https://www.ntnu.no/ansatte/erik.solligard, www.sepsis.no

Jan Kristian Damås

MD PhD, Professor and Senior Consultant in Infec8ous Diseases Centre of molecular inflamma8on research (CEMIR), NTNU, St Olavs Hospital, University Hospital Trondheim
Email: jan.k.damas@ntnu.no
Phone: +47 91112046
Website: https://www.ntnu.no/ansaae/jan.k.damas, www.sepsis.no

Copenhagen University/Rigshospitalet, Copenhagen; Denmark

Copenhagen University/Rigshospitalet, Copenhagen; Denmark

Key contributors:

Ole Hyldegaard

Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
Email: Ole.Hyldegaard@regionh.dk

Wageningen University & Research, Wageningen, the Netherlands

Wageningen University & Research, Wageningen, the Netherlands

Non-funded partner

Laboratory of Systems and Synthetic Biology

Key contributors:

Edoardo Saccenti

Assistant Professor
Email: edoardo.saccenti@wur.nl
Phone: +31 (0)317 486948
Website: https://www.systemsbiology.nl/edoardo-saccenti/

LifeGlimmer GmbH, Berlin, Germany

LifeGlimmer GmbH, Berlin, Germany