Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

Elin Movert, Jaume Salgado Bolarin, Christine Valfridsson, Jorge Velarde, Steinar Skrede, Michael Nekludov, Ole Hyldegaard, Per Arnell, Mattias Svensson, Anna Norrby-Teglund, Kyu Hong Cho, Michael Wessels, Lars Råberg and Fredric Carlsson

Nature Communications, volume 14:4008 (2023)

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

Neutrophil-derived reactive agents induce a speB negative phenotype in Streptococcus pyogenes

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study

Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections

New biomarkers for life-threatening soft tissue infections

31st May -1st June 2021, PerAID Annual Meeting

18-19th May 2021, ERAPerMed Midterm Review Seminar

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Necrotizing Soft Tissue Infections Clinical and Pathogenic Aspects

Host and Pathogen Communication in the Respiratory Tract: Mechanisms and Models of a Complex Signaling Microenvironment

28th January 2021, PerMIT and PerAID Project Meetings

4th September 2020, PerMIT Annual Meeting

21st August, 2020, Doctoral Thesis Defense, Puran Chen

Research highlighted in “Forskning och Framsteg”

Risk factors and predictors of mortality in Streptococcal necrotizing soft-tissue infections: A multicenter prospective study

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections.

Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections

27-29 May 2020, PerAID Annual Meeting

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

23 – 26 Oct 2019, PerMIT 1st annual meeting

17 – 18 Sept 2019: Nordic PerMed workshop, Oslo

Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response.

Necrotizing Soft Tissue Infections S.aureus – but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

Health-Related Quality of Life Is Decreased After Necrotizing Soft-Tissue Infections

12 – 15 sept 2019: Nordic Society for Clinical Microbiology and Infectious Diseases (NSCMID), Trondheim.

Necrotizing skin and soft-tissue infections in the intensive care unit.

Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

Almedalsveckan

GenomeWeb highlighting PerAID in their publication of Nordforsk projects

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