PUBLICATIONS
Here we will continuously publish articles from studies within the projects PerAid, PerMIT and INFECT.
Neutrophil-derived reactive agents induce a speB negative phenotype in Streptococcus pyogenes
Neutrophil-derived reactive agents induce a speB negative phenotype in Streptococcus pyogenes
Patience Shumba, Thomas Sur, Kirsten Moll, Bhavya Chakrakodi, Jörn Hoßmann, Katharina J. Hoff, Ole Hyldegaard, Michael Nekludov, Mattias Svensson, Per Arnell, Steinar Skrede, Anna Norrby-Teglund and Nikolai Siemens
Journal of Biomedical Sciences, 2023, volume 30:52
Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
Elin Movert, Jaume Salgado Bolarin, Christine Valfridsson, Jorge Velarde, Steinar Skrede, Michael Nekludov, Ole Hyldegaard, Per Arnell, Mattias Svensson, Anna Norrby-Teglund, Kyu Hong Cho, Michael Wessels, Lars Råberg and Fredric Carlsson
Nature Communications, 2023, volume 14:4008
Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study
Eivind Rath, Laura M. Palma Medina, Sanjeevan Jahagirdar, Knut A. Mosevoll, Jan K. Damås, Martin B. Madsen, Mattias Svensson, Ole Hyldegaard, Vitor A. P. Martins dos Santos, INFECT Study group*, Edoardo Saccenti, Anna Norrby-Teglund, Steinar Skrede and Trond Bruun
Clinical Immunology, 2023, volume 249: 109276
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
Sanjeevan Jahagirdar, Lorna Morris, Nirupama Benis, Oddvar Oppegaard, Mattias Svenson, Ole Hyldegaard, Steinar Skrede, Anna Norrby-Teglund, INFECT Study group, Vitor A. P. Martins dos Santos, Edoardo Saccenti
BMC Medicine, 2022; volume 20: 173
Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models
Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models
H Bergsten, L M Palma Medina, M Morgan, K Moll, D H Skutlaberg, S Skrede, T Wajima, M Svensson, A Norrby-Teglund
Antimicrob Agents Chemother, 2021; 65:e0065821
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19
Magda Lourda, Majda Dzidic, Laura Hertwig, Helena Bergsten, Laura M Palma Medina, Indranil Sinha, Egle Kvedaraite, Puran Chen, Jagadeeswara R Muvva , Jean-Baptiste Gorin, Martin Cornillet, Johanna Emgård, Kirsten Moll, Marina García, Kimia T Maleki, Jonas Klingström, Jakob Michaëlsson, Malin Flodström-Tullberg, Susanna Brighenti, Marcus Buggert, Jenny Mjösberg, Karl-Johan Malmberg, Johan K Sandberg, Jan-Inge Henter, Elin Folkesson, Sara Gredmark-Russ, Anders Sönnerborg, Lars I Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Strålin, Hans-Gustaf Ljunggren, Niklas K Björkström, Mattias Svensson, Andrea Ponzetta, Anna Norrby-Teglund, Benedict J Chambers, Karolinska KI/K COVID-19 Study Group
Proc Natl Acad Sci U S A, 2021; 118:e2109123118
Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections
J Clin Invest. 2021;131(14):e149523
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingström, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars I. Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Strålin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Björkström, Jan-Inge Henter, Mattias Svensson, and Karolinska KI/K COVID-19 Study Group
PNAS February 9, 2021;118:e2018587118
Evaluation of Single Sample Network Inference Methods for Metabolomics-Based Systems Medicine
Evaluation of Single Sample Network Inference Methods for Metabolomics-Based Systems Medicine
Sanjeevan Jahagirdar and Edoardo Saccenti
Journal of Proteome Research, 2021, 20, 1, 932–949
Soluble ICAM-1 is modulated by hyperbaric oxygen treatment and correlates with disease severity and mortality in patients with necrotizing soft-tissue infection
Phenotype and multi-omics comparison of Staphylococcus and Streptococcus uncovers pathogenic traits and predicts zoonotic potential
Niels A. Zondervan, Vitor A. P. Martins dos Santos, Maria Suarez-Diez and Edoardo Saccenti
BMC Genomics, 2021;22: Article 102
Host and Pathogen Communication in the Respiratory Tract: Mechanisms and Models of a Complex Signaling Microenvironment
Samuel B Berry, Amanda J Haack, Ashleigh B Theberge, Susanna Brighenti, Mattias Svensson
Frontiers in Medicine, 2020, Volume 7, Article 537
Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections
Clinical Infectious Diseases, Volume 71, Issue 7, 1 October 2020, Pages 1772–1775
Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study
Clinical Infectious Diseases, Volume 72, Issue 2, 15 January 2021, Pages 293–300
Non-purulent skin and soft tissue infections: predictive power of a severity score and the appropriateness of treatment in a prospective cohort
Infectious Diseases, 2020, 52:361-371
Corruption of the Pearson correlation coefficient by measurement error and its estimation, bias, and correction under different error models
Edoardo Saccenti, Margriet H. W. B. Hendriks and Age K. Smilde
Scientific Reports, 2020;10: Article 438
Incidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005-2018: a Danish nationwide register-based cohort study
The INFECT-Project: An International and Multidisciplinary Project on Necrotizing Soft Tissue Infections
Advances in Experimental Medicine and Biology, 2020;1294:1-6
Necrotizing Soft Tissue Infections: Case Reports from the Patients Prospective
Necrotizing Soft Tissue Infections: Case Reports from the Patients Prospective
Advances in Experimental Medicine and Biology, 2020;1294:7-20
Necrotizing Soft Tissue Infections: Case Reports, from the Clinician’s Perspectives
Necrotizing Soft Tissue Infections: Case Reports, from the Clinician’s Perspectives
Advances in Experimental Medicine and Biology, 2020;1294:21-37
Necrotizing Soft-Tissue Infections: Clinical Features and Diagnostic Aspects
Necrotizing Soft-Tissue Infections: Clinical Features and Diagnostic Aspects
Advances in Experimental Medicine and Biology, 2020;1294:39-52
Microbiological Etiology of Necrotizing Soft Tissue Infections
Microbiological Etiology of Necrotizing Soft Tissue Infections
Advances in Experimental Medicine and Biology, 2020;1294:53-71
Beta-Hemolytic Streptococci and Necrotizing Soft Tissue Infections
Beta-Hemolytic Streptococci and Necrotizing Soft Tissue Infections
Advances in Experimental Medicine and Biology, 2020;1294:73-86
Treatment of Necrotizing Soft Tissue Infections: Antibiotics
Treatment of Necrotizing Soft Tissue Infections: Antibiotics
Advances in Experimental Medicine and Biology, 2020;1294:87-103
Treatment of Necrotizing Soft Tissue Infections: IVIG
Treatment of Necrotizing Soft Tissue Infections: IVIG
Advances in Experimental Medicine and Biology, 2020;1294:105-125
Pathogenic Mechanisms of Streptococcal Necrotizing Soft Tissue Infections
Pathogenic Mechanisms of Streptococcal Necrotizing Soft Tissue Infections
Advances in Experimental Medicine and Biology, 2020;1294:127-150
Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections
Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections
Advances in Experimental Medicine and Biology, 2020;1294:151-166.
Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections
Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections
Advances in Experimental Medicine and Biology, 2020;1294:167-186
Models of the lung tissue microenvironment for studies of human myeloid cell function
Models of the lung tissue microenvironment for studies of human myeloid cell function
Puran Chen, Doctoral Thesis, August 21st 2020
Necrotizing skin and soft-tissue infections in the intensive care unit
Necrotizing skin and soft-tissue infections in the intensive care unit
M.Peetermans, N.de Prost, C.Eckmann, A.Norrby-Teglund, S.Skrede, J.J.De Waele
Clinical Microbiology and Infection; 2020, 26:8-17
Integrated univariate, multivariate and correlation-based network analyses reveal metabolite-specific effects on bacterial growth and biofilm formation in necrotizing soft tissue infections
Muhammad Afzal, Edoardo Saccenti, Martin Madsen, Marco Bo Hansen, Ole Hyldegaard, Steinar Skrede, vitor martins dos santos, Anna Norrby Teglund and Mattias Svensson
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome
Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment
Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment
Siemens N., Oehmcke-Hecht S., Hoßmann J.. Skorka S.B., Nijhuis R.H.T. Ruppen C., Skrede S., · Rohde M., Schultz D., Lalk M., Itzek A., Pieper D.H., van den Bout C.J., Claas E.C.J., Kuijper E.J., Mauritz R., Sendi P., Wunderink H.F., and Norrby-Teglund A.
Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
Robert Thänert, Andreas Itzek, Jörn Hoßmann, Domenica Hamisch, Martin Bruun Madsen, Ole Hyldegaard, Steinar Skrede, Trond Bruun & Anna Norrby-Teglund INFECT study group, Eva Medina & Dietmar H. Pieper, Nature Communications, 26 August 2019, volume 10, Article number: 3846.
Patient’s characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study
Martin Bruun Madsen, Steinar Skrede, Anders Perner, Per Arnell, Michael Nekludov, Trond Bruun, Ylva Karlsson, Marco Bo Hansen, Peter Polzik, Morten Hedetoft, Anders Rosén, Edoardo Saccenti, François Bergey, Vitor A. P. Martins dos Santos, INFECT study group, Anna Norrby-Teglund, Ole Hyldegaard, Intensive Care Medicine, September 2019, Volume 45, Issue 9, pp 1241–1251, Doi:10.1007/s00134-019-05730-x, PMID: 31440795
Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?
Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?
Norrby-Teglund A, Siemens N. Clin Infect Dis. 2019 Jul 23. pii: ciz427. doi: 10.1093/cid/ciz427. [Epub ahead of print]. PMID: 31334751
Necrotizing skin and soft-tissue infections in the intensive care unit.
Necrotizing skin and soft-tissue infections in the intensive care unit.
Peetermans M, de Prost N, Eckmann C, Norrby-Teglund A, Skrede S, De Waele JJ. Clin Microbiol Infect. 2019 Jul 5. pii: S1198-743X(19)30382-9. doi: 10.1016/j.cmi.2019.06.031. [Epub ahead of print] Review. PMID: 31284035
Necrotizing Soft Tissue Infections S.aureus - but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.
Baude J, Bastien S, Gillet Y, Leblanc P, Itzek A, Tristan A, Bes M, Duguez S, Moreau K, Diep BA, Norrby-Teglund A, Henry T, Vandenesch F; INFECT Study Group. J Infect Dis. 2019 Apr 19. pii: jiz167. doi: 10.1093/infdis/jiz167. [Epub ahead of print] PMID:31001627
Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response.
Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response.
Keller N, Woytschak J, Heeb LEM, Marques Maggio E, Mairpady Shambat S, Snäll J, Hyldegaard O, Boyman O, Norrby-Teglund A, Zinkernagel AS. J Invest Dermatol. 2019 Jun;139(6):1284-1293. doi: 10.1016/j.jid.2018.11.027. Epub 2018 Dec 10. PMID: 30543898
Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.
Tarnutzer A, Andreoni F, Keller N, Zürcher C, Norrby-Teglund A, Schüpbach RA, Zinkernagel AS. Clin Microbiol Infect. 2019 Apr;25(4):512.e7-512.e13. doi: 10.1016/j.cmi.2018.07.007. Epub 2018 Jul 17. PMID: 30025835
